Reaktion #341082

ord-8b484f7758bd48feadaaca6b3416cb56

Reaktionsgleichung

ClCC=NCCCCCCCl
2-(hexamethyleneimino)ethylchloride
CC(=O)N1CCC(N(C(=O)Nc2ncc(SC#N)s2)C2CCCCC2)CC1
1-(1-acetyl-piperidin-4-yl)-1-cyclohexyl-3-(5-thiocyanato-thiazol-2-yl)-urea
O[C@H](CS)[C@@H](O)CS
dithioerythritol
→
CC(=O)N1CCC(N(C(=O)Nc2ncc(SCCN3CCCCCC3)s2)C2CCCCC2)CC1
1-(1-Acetyl-piperidin-4-yl)-3-[5-(2-azepan-1-yl-ethylsulfanyl)-thiazol-2-yl]-1-cyclohexyl-urea

Edukte

ClCC=NCCCCCCCl
2-(hexamethyleneimino)ethylchloride
—
( I )
CC(=O)N1CCC(N(C(=O)Nc2ncc(SC#N)s2)C2CCCCC2)CC1
1-(1-acetyl-piperidin-4-yl)-1-cyclohexyl-3-(5-thiocyanato-thiazol-2-yl)-urea
O[C@H](CS)[C@@H](O)CS
dithioerythritol

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigePrepared

Vorschrift

Prepared as described in general procedures (H) and (I) using 1-(1-acetyl-piperidin-4-yl)-1-cyclohexyl-3-(5-thiocyanato-thiazol-2-yl)-urea, dithioerythritol and 2-(hexamethyleneimino)ethylchloride

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07872139B2uspto-grants-2011_01