Reaktion #341079

ord-30dc8794e8f64048af05c23e8c467a2e

Reaktionsgleichung

N#CSc1cnc(NC(=O)N(C2CCCCC2)C2CCCCC2)s1
1,1-dicyclohexyl-3-(5-thiocyanato-thiazol-2-yl)-urea
O[C@H](CS)[C@@H](O)CS
dithioerythritol
ClCCc1nnn[nH]1
5-(2-chloroethyl)-1H-tetrazole
→
O=C(Nc1ncc(SCCc2nnn[nH]2)s1)N(C1CCCCC1)C1CCCCC1
1,1-Dicyclohexyl-3-{5-[2-(1H-tetrazol-5-yl)-ethylsulfanyl]-thiazol-2-yl}-urea

Edukte

N#CSc1cnc(NC(=O)N(C2CCCCC2)C2CCCCC2)s1
1,1-dicyclohexyl-3-(5-thiocyanato-thiazol-2-yl)-urea
O[C@H](CS)[C@@H](O)CS
dithioerythritol
ClCCc1nnn[nH]1
5-(2-chloroethyl)-1H-tetrazole

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigePrepared

Vorschrift

Prepared as described in general procedure (H) using 1,1-dicyclohexyl-3-(5-thiocyanato-thiazol-2-yl)-urea, dithioerythritol and 5-(2-chloroethyl)-1H-tetrazole.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07872139B2uspto-grants-2011_01