Reaktion #3410

Reaktionsgleichung

7a-(5-bromo-3-pyridinyl)-hexahydro-1H-pyrrolizine

Et2O

HCl

→

title compound

7a-(5-bromo-3-pyridinyl)-hexahydro-1H-pyrrolizine hydrochloride salt

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was removed
2. 2
   Sonstigethe solid was crystallized from MeOH/Et2O
3. 3
   Sonstigedried

Vorschrift

7a-(5-bromo-3-pyridinyl)-hexahydro-1H-pyrrolizine (107 mg, 0.52 mmol, from step 16c) was dissolved in methylene chloride, and Et2O saturated with HCl (g) was added. The solvent was removed, and the solid was crystallized from MeOH/Et2O and dried to afford the title compound as an off-white powder (118 mg). mp 192°-194° C. 1H NMR D2O, 300 MHz) δ2.13-2.51 (m, 6H), 2.57-2.66 (m, 2H), 3.36-3.44 (m, 2H), 3.81-3.89(m, 2H), 8.22 (s, 1H), 8.65 (s, 1H), 8.72 (s, 1H); MS (CI/NH3) m/z: 267/269 (M+H)+. Anal. Calcd for C12 H15BrN2.HCl: C, 47.47; H, 5.31; N, 9.23. Found: C, 47.40; H, 5.22; N, 8.98.

Quelle