Reaktion #3408

Reaktionsgleichung

7a-(3-Hydroxy-5-pyridinyl)-hexahydro-1H-pyrrolizine

Et2O

HCl

→

title compound

Ausbeute 91.0%

7a-(3-hydroxy-5-pyridinyl)-hexahydro-1H-pyrrolizine hydrochloride salt

Ausbeute 91.0%

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was removed
2. 2
   Sonstigethe solid was dried

Vorschrift

7a-(3-Hydroxy-5-pyridinyl)-hexahydro-1H-pyrrolizine (150 mg, 0.56 mmol, from step 16c) was dissolved in methylene chloride, and Et2O saturated with HCl (g) was added. The solvent was removed, and the solid was dried to afford the title compound as a white powder (114 mg, 91%): mp 175°-180° C. (dec.); 1H NMR D2O, 300 MHz) δ2.11-2.63 (m, 8H), 3.35-3.44 (m, 2H), 3.80-3.89 (m, 2H), 7.66 (dd, J=2.4, 2.0 Hz, 1H), 8.23 (d, J=2.4 Hz, 1H), 8.29 (d, J=2.0 Hz, 1H); MS (CI/NH3) m/z: 205 (M+H)+. Anal. Calcd for C12H16N2O.HCl: C, 53.40; H, 6.65; N, 10.38. Found: C, 53.55; H, 6.62; N, 10.24.

Quelle