Reaktion #340704

Reaktionsgleichung

1-chloro-2-methylpropyl methylformate

sodium methanethiolate

→

title compound ( 6a )

1-Chloro-2-methylpropyl methylthioformate

Lösungsmittel

dichloromethane

water

dichloromethane

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto separate
2. 2
   Waschenwashed with water and brine
3. 3
   Trocknendried with anhydrous sodium sulfate (Na2SO4)
4. 4
   SonstigeAfter rotary evaporation
5. 5
   Sonstigeto remove the solvent

Vorschrift

To a stirred solution of 1-chloro-2-methylpropyl methylformate in dichloromethane (DCM) was added a solution of sodium methanethiolate (CH3—SNa) (1.0 eq.) in water at 0° C. and 0.02 eq. of tetrabutylammonium bromide. The reactants were stirred at 0° C. for 30 min and then diluted with dichloromethane (DCM). The dichloromethane layer was allowed to separate, then washed with water and brine, and dried with anhydrous sodium sulfate (Na2SO4). After rotary evaporation to remove the solvent, the title compound (6a) was obtained. 1H-NMR (CDCl3): δ 1.05 (d, J=5.6 Hz, 3H), 1.07 (d, J=5.6 Hz, 3H), 2.18 (m, 1H), 2.38 (s, 3H), 6.34 (d, J=5.6 Hz, 1H) ppm.

Quelle