Reaktion #340657

Reaktionsgleichung

water

bromoethane

4-(1H-benzoimidazol-2-ylmethoxy)-2-fluoro-5-methoxy-benzaldehyde

4-(1H-Benzoimidazol-2-ylmethoxy)-2-fluoro-5-methoxy-benzaldehyde

sodium hydride

→

desired compound

Ausbeute 89.0%

4-(1-ethyl-1H-benzoimidazol-2-ylmethoxy)-2-fluoro-5-methoxy-benzaldehyde

Ausbeute 89.0%

Lösungsmittel

N,N-dimethylacetamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONAfter the addition
2. 2
   workup.ADDITIONwas added
3. 3
   workup.STIRRINGwith stirring
4. 4
   Filtrationthe precipitated solid was filtered
5. 5
   Waschenwashed with water
6. 6
   Sonstigedried

Vorschrift

To a solution of 4-(1H-benzoimidazol-2-ylmethoxy)-2-fluoro-5-methoxy-benzaldehyde (215, 4.0 g, 13 mmol) in N,N-dimethylacetamide (80 mL) was added sodium hydride (60% dispersion in mineral oil, 0.65 g, 16 mmol) portion wise. After the addition was complete, the reaction was stirred for 30 minutes after which bromoethane (1.2 mL, 16 mmol) was added and then allowed to stir for several hours. The reaction mixture was then poured into water (1 L) with stirring and the precipitated solid was filtered, washed with water and dried to give the desired compound (216, 3.8 g, 87% yield).

Quelle