Reaktion #340508

Reaktionsgleichung

Rongalit

2-fluoro-4-methyl-5-mercaptoaniline

2,2,2-trifluoroethyl iodide

potassium carbonate

→

2-fluoro-4-methyl-5-(2,2,2-trifluoroethylthio)aniline

Ausbeute 92.7%

Lösungsmittel

N,N-dimethylformamide

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction liquid
2. 2
   Extraktionthe mixture was extracted with ethyl acetate
3. 3
   Trocknenthe organic layer was dried over anhydrous magnesium sulfate
4. 4
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure

Vorschrift

To 1,000 ml of a N,N-dimethylformamide solution of 129 g of 2-fluoro-4-methyl-5-mercaptoaniline, 250 g of 2,2,2-trifluoroethyl iodide and 125 g of potassium carbonate were added, and 10 g of Rongalit was further added, followed by stirring at room temperature for 8 hours. The reaction liquid was poured into water, the mixture was extracted with ethyl acetate, the organic layer was dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure to obtain 182 g of 2-fluoro-4-methyl-5-(2,2,2-trifluoroethylthio)aniline.

Quelle