Reaktion #340244

Reaktionsgleichung

1-aminocyclohexanecarboxylic acid

tetrahydrofuran-methanol

(trimethylsilyl) diazomethane

→

1-amino-1-methoxy-carbonylcyclohexane

Ausbeute 52.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooling
2. 2
   EinengenThe reaction mixture was concentrated in vacuo and to the residue
3. 3
   workup.ADDITIONwas added diethyl ether-hexane (1/1)
4. 4
   workup.ADDITIONThereto was added 4M HCl-ethyl acetate (1.05 mL)
5. 5
   Filtrationthe precipitates were collected by filtration
6. 6
   Sonstigedried

Vorschrift

A solution of 1-aminocyclohexanecarboxylic acid (600 mg) in tetrahydrofuran-methanol was stirred under ice-cooling. Thereto was added dropwise a (trimethylsilyl) diazomethane solution (4.2 mL) and the mixture was stirred overnight. The reaction mixture was concentrated in vacuo and to the residue was added diethyl ether-hexane (1/1). Thereto was added 4M HCl-ethyl acetate (1.05 mL) and the precipitates were collected by filtration and dried to give 1-amino-1-methoxy-carbonylcyclohexane (423 mg, yield: 52%) as a white powder.

Quelle