Reaktion #340113

Reaktionsgleichung

hydrochloric acid

tert.-butyl 1-(thiazol-2-yl)pyrrolidin-3-ylcarbamate

→

1-(thiazol-2-yl)pyrrolidin-3-amine hydrochloride

Ausbeute 97.0%

Lösungsmittel

MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeevaporated under a vacuum

Vorschrift

Aq. conc. hydrochloric acid (2 ml) was added to a solution of 890 mg (3.3 mmol) of tert.-butyl 1-(thiazol-2-yl)pyrrolidin-3-ylcarbamate in MeOH (20 ml). The reaction solution was stirred at RT for 16 h and then evaporated under a vacuum. 653 mg (3.2 mmol, 97%) of 1-(thiazol-2-yl)pyrrolidin-3-amine hydrochloride were obtained by crystallising the residue from an ethanol/ether mixture.

Quelle