Reaktion #339896

Reaktionsgleichung

N-{5-[6-chloro-5-(5-chloro-1,3-dimethyl-1H-pyrazol-4-ylsulfonamido)pyridin-3-yl]-4-methyl-1,3-thiazol-2-yl}acetamide

hydrochloric acid

→

title compound

Ausbeute 36.6%

N-[5-(2-Amino-4-methyl-1,3-thiazol-5-yl)-2-chloropyridin-3-yl]-5-chloro-1,3-dimethyl-1H-pyrazole-4-sulfonamide

Ausbeute 36.6%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was cooled to room temperature
2. 2
   Einengenconcentrated by evaporation
3. 3
   SonstigeThe residue was purified by preparative HPLC

Vorschrift

A mixture of N-{5-[6-chloro-5-(5-chloro-1,3-dimethyl-1H-pyrazol-4-ylsulfonamido)pyridin-3-yl]-4-methyl-1,3-thiazol-2-yl}acetamide (300 mg), a 6N aqueous hydrochloric acid solution (5 mL) and ethanol (5 mL) was stirred and heated to 80° C. for 5 hours. The mixture was cooled to room temperature and concentrated by evaporation. The residue was purified by preparative HPLC. There was thus obtained the title compound as a white solid (100 mg); 1H NMR Spectrum: (DMSOd6) 2.19 (s, 6H), 3.73 (s, 3H), 7.39 (br s, 2H), 7.66 (s, 1H), 8.25 (s, 1H); Mass Spectrum: M+H+ 433.

Quelle