Reaktion #339873

Reaktionsgleichung

hydrochloric acid

sodium boron hydride

water

methyl 2-hydroxy-3,3,3-trifluoro-2-trifluoromethylpropionate

→

3,3,3-trifluoro-2-trifluoromethyl-1,2-propane diol

Ausbeute 96.0%

Lösungsmittel

diethyl ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGThe mixture was stirred for 10 hours
2. 2
   Sonstigeto quench
3. 3
   Sonstigethe reaction
4. 4
   SonstigeAn organic layer was separated from the reaction mixture
5. 5
   Einengenconcentrated
6. 6
   workup.DISTILLATIONdistilled

Vorschrift

To a mixture of 25.0 g of sodium boron hydride, 500 g of water, and 500 g of diethyl ether, with stirring, 100 g of methyl 2-hydroxy-3,3,3-trifluoro-2-trifluoromethylpropionate was added dropwise. The mixture was stirred for 10 hours, after which hydrochloric acid was added to quench the reaction. An organic layer was separated from the reaction mixture, concentrated, and distilled, obtaining 83.9 g of 3,3,3-trifluoro-2-trifluoromethyl-1,2-propane diol (yield 96%).

Quelle