Reaktion #339769

Reaktionsgleichung

2-(4-aminophenyl)-1-ethyl-6-methoxy-1H-indole-3-carbonitrile

4-chloro-2-phenyl-quinazoline

diisopropylethylamine

→

1-ethyl-6-methoxy-2-[4-(2-phenylquinazolin-4-ylamino)-phenyl]-1H-indole-3-carbonitrile

Ausbeute 82.4%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto reflux overnight
2. 2
   TemperaturThe solution is cooled
3. 3
   Sonstigeevaporated
4. 4
   WaschenThis is washed with water and saturated brine (50 mL each)
5. 5
   Trocknendried over anhydrous sodium sulfate
6. 6
   Filtrationfiltered
7. 7
   Sonstigeevaporated
8. 8
   SonstigeThe resulting solid is triturated with ether
9. 9
   Filtrationcollected by filtration
10. 10
    Sonstigedried under vacuum

Vorschrift

A solution of 2-(4-aminophenyl)-1-ethyl-6-methoxy-1H-indole-3-carbonitrile (100 mg, 0.343 mmol), 4-chloro-2-phenyl-quinazoline (83 mg, 0.34 mmol) and diisopropylethylamine (0.10 mL, 0.57 mmol) in absolute ethanol (3 mL) is heated to reflux overnight. The solution is cooled and evaporated, and the residue taken up in ethyl acetate (50 mL). This is washed with water and saturated brine (50 mL each), then dried over anhydrous sodium sulfate, filtered and evaporated. The resulting solid is triturated with ether, collected by filtration and dried under vacuum to afford 1-ethyl-6-methoxy-2-[4-(2-phenylquinazolin-4-ylamino)-phenyl]-1H-indole-3-carbonitrile (139 mg, 0.280 mmol, 82%).

Quelle