Reaktion #3395

Reaktionsgleichung

HCl

7a-(5-fluoro-3-pyridinyl)-hexahydro-1H-pyrrolizine

→

solid

Ausbeute 69.0%

7a-(5-fluoro-3-pyridinyl)-hexahydro-1H-pyrrolizine hydrochloride salt

Ausbeute 69.0%

Lösungsmittel

Et2O

Et2O

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was removed
2. 2
   Sonstigethe precipitate was triturated with

Vorschrift

7a-(5-fluoro-3-pyridinyl)-hexahydro-1H-pyrrolizine (62 mg, 0.24 mmol, from step 12d) was dissolved in Et2O, and Et2O saturated with HCl (g) was added. The solvent was removed, and the precipitate was triturated with to give a white solid (57.1 mg, 69%). mp 168°-169° C. 1H NMR D2O, 300 MHz) 67 2.13-2.50 (m, 6H), 2.58-2.67 (m, 2H), 3.34-3.42 (m, 2H), 3.78-3.87 (m, 2H), 7.24 (dd, J=8.8, 2.4, Hz, 1H), 8.13 (ddd, J=8.8, 7.2, 2.7 Hz, 1H), 8.36 (dd, J=2.7, 1.4 Hz, 1H); MS (CI/NH3) m/z: 207 (M+H)+. Anal. Calcd for Cl12H16 ClFN2 : C, 59.38; H, 6.64; N, 11.54. Found: C, 59.51; H, 6.52; N, 11.30.

Quelle