Reaktion #339058

Reaktionsgleichung

(R)-2-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-yl)phenylamine

2-chloroethyl chloroformate

→

desired product

Ausbeute 108.6%

3-[2-((R)-6,8-Dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl]-oxazolidin-2-one

Ausbeute 108.6%

Reaktionsbedingungen

Vorschrift

Analogously to example 45a), (R)-2-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-yl)phenylamine (300 mg, enantiomer B, preparation as described in WO2004085404) was reacted with 2-chloroethyl chloroformate (140 mg). 400 mg of the desired product were obtained.

Quelle