Reaktion #338946

Reaktionsgleichung

2-(4-iodophenyl)-imidazo [1,2-a] pyridine

10-bromoanthracene-9-boronic acid

sodium carbonate

→

2-[4-(10-bromo-anthracene-9-yl)-phenyl]-imidazo [1,2-a] pyridine

Ausbeute 78.9%

Lösungsmittel

1,2-dimethoxyethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturunder heating for 7 hours
2. 2
   SonstigeAfter completion of the reaction, separation
3. 3
   Filtrationwith filtration
4. 4
   Waschenresultant crystals were washed with water and methanol

Vorschrift

Ten point six grams (33 mmol) of 2-(4-iodophenyl)-imidazo [1,2-a] pyridine, 10 g (33 mmol) of 10-bromoanthracene-9-boronic acid and 0.77 g of tetrakis (triphenylphosphine) palladium were dissolved into 100 milliliter of 1,2-dimethoxyethane, and adding 50 milliliter of 2.0M sodium carbonate aqueous solution, the resultant suspension was refluxed under heating for 7 hours. After completion of the reaction, separation with filtration was carried out and resultant crystals were washed with water and methanol, thereby obtaining 11.7 g of 2-[4-(10-bromo-anthracene-9-yl)-phenyl]-imidazo [1,2-a] pyridine (yield: 78%).

Quelle