Reaktion #337872

Reaktionsgleichung

TFA

aniline

588

6-bromo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine

bromide

biphenyl-2-yl-di-tert-butyl-phosphane

NaOtBu

→

desired compound

N-phenyl-1H-pyrrolo[2,3-b]pyridin-6-amine

Lösungsmittel

toluene

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added
2. 2
   Sonstigewas prepared
3. 3
   Sonstigewas placed in an 80° C.
4. 4
   Sonstigefor 60 minutes
5. 5
   TemperaturAfter cooling
6. 6
   SonstigeAfter 30 minutes the sample was evaporated

Vorschrift

A 1 dram vial was charged with aniline (2-3 equiv), and 0.200 mL of the 588 stock solution of bromide in toluene was added. A catalyst stock solution containing 3 mmol Pd(OAc)2, 3 mmol biphenyl-2-yl-di-tert-butyl-phosphane and 15 mL of toluene was prepared and 0.050 mL of the catalyst solution was added to the reaction. An excess of NaOtBu was added as a solid to the reaction. The vial was placed in an 80° C. oven for 60 minutes (shaken several times over the hour). After cooling, the reaction was neutralized with 0.100 mL of TFA. After 30 minutes the sample was evaporated and resolvated in 0.300 mL of DMSO. The desired compound was isolated by preparative HPLC/MS. MS (ESI) [M+H+]+=210.4.

Quelle