Reaktion #337721

Reaktionsgleichung

HCl

cyclobutane carboxylic acid

LDA

bromoethylcyclopropane

→

title compound

Ausbeute 124.5%

1-(cyclopropylmethyl)cyclobutanecarboxylic acid

Ausbeute 124.5%

Lösungsmittel

THF

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe mixture was stirred at RT
2. 2
   Sonstigeovernight
3. 3
   Extraktionthe mixture was extracted with EtOAc
4. 4
   WaschenThe organic layer was washed with water and brine

Vorschrift

To a solution of LDA (100 ml, 2.0 M THF solution) in THF (100 ml) was added dropwise over a period of 20 minutes at 0° C., a solution of cyclobutane carboxylic acid (10 g, 0.1 mol) in THF (15 ml). The resulting mixture was stirred at RT for 2 h then bromoethylcyclopropane (15 g, 0.11 mol) was added dropwise and the mixture was stirred at RT. overnight. To the reaction mixture was added 2N HCl and the mixture was extracted with EtOAc. The organic layer was washed with water and brine to afford the title compound as light yellow oil (19.2 g), which was used in the next step without purification.

Quelle