Reaktion #337516

ord-3bca63a8cd194df4af0b9dbe35d3af4a

Reaktionsgleichung

CCCCOC(=O)c1ncc2cc(Oc3ccccc3)ccc2c1O
4-hydroxy-7-phenoxy-isoquinoline-3-carboxylic acid butyl ester
C[C@@H](N)C(=O)O
D-alanine
→
C[C@@H](NC(=O)c1ncc2cc(Oc3ccccc3)ccc2c1O)C(=O)O
2-(R)-[(4-Hydroxy-7-phenoxy-isoquinoline-3-carbonyl)-amino]-propionic acid

Edukte

CCCCOC(=O)c1ncc2cc(Oc3ccccc3)ccc2c1O
4-hydroxy-7-phenoxy-isoquinoline-3-carboxylic acid butyl ester
C[C@@H](N)C(=O)O
D-alanine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigePrepared in analogy to Example A-63 g)
  2. 2
    Sonstigefor 5 days

Vorschrift

Prepared in analogy to Example A-63 g) by reacting 4-hydroxy-7-phenoxy-isoquinoline-3-carboxylic acid butyl ester with D-alanine at the reflux condition for 5 days. MS-(−)-ion: M−1=351.1.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07863292B2uspto-grants-2011_01