Reaktion #337083

ord-9a0eb9cab11d48e58986688fb6f171db

Reaktionsgleichung

COC(=O)c1cccc2oc(N3[C@@H](C)CN(C(C)=O)C[C@@H]3C)nc12
methyl 2-((2S,6S)-4-acetyl-2,6-dimethylpiperazin-1-yl)benzoxazole-4-carboxylate
O.[Li+].[OH-]
lithium hydroxide monohydrate
→
CC(=O)N1C[C@H](C)N(c2nc3c(C(=O)[O-])cccc3o2)[C@@H](C)C1.[Li+]
lithium 2-((2S,6S)-4-acetyl-2,6-dimethylpiperazin-1-yl)benzoxazole-4-carboxylate

Edukte

COC(=O)c1cccc2oc(N3[C@@H](C)CN(C(C)=O)C[C@@H]3C)nc12
methyl 2-((2S,6S)-4-acetyl-2,6-dimethylpiperazin-1-yl)benzoxazole-4-carboxylate
O.[Li+].[OH-]
lithium hydroxide monohydrate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following general procedure GP-B2, methyl 2-((2S,6S)-4-acetyl-2,6-dimethylpiperazin-1-yl)benzoxazole-4-carboxylate was reacted with lithium hydroxide monohydrate to provide lithium 2-((2S,6S)-4-acetyl-2,6-dimethylpiperazin-1-yl)benzoxazole-4-carboxylate. 1H NMR and MS consistent.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07863271B2uspto-grants-2011_01