Reaktion #337024

ord-a0a680c7f71f4cbf8f5820a6d796aa77

Reaktionsgleichung

O=C(O)c1cccc2oc(Nc3ccncc3)nc12
2-(pyridin-4-ylamino)benzoxazole-4-carboxylic acid
Cl.Cl.N[C@@H]1CN2CCC1CC2
(S)-(−)-3-aminoquinuclidine dihydrochloride
→
O=C(N[C@@H]1CN2CCC1CC2)c1cccc2oc(Nc3ccncc3)nc12
(S)—N-(quinuclidine-8-yl)-2-(pyridin-4-ylamino)benzoxazole-4-carboxamide

Edukte

O=C(O)c1cccc2oc(Nc3ccncc3)nc12
2-(pyridin-4-ylamino)benzoxazole-4-carboxylic acid
Cl.Cl.N[C@@H]1CN2CCC1CC2
(S)-(−)-3-aminoquinuclidine dihydrochloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following general procedure GP-C1, a mixture of 2-(pyridin-4-ylamino)benzoxazole-4-carboxylic acid and (S)-(−)-3-aminoquinuclidine dihydrochloride were coupled to provide (S)—N-(quinuclidine-8-yl)-2-(pyridin-4-ylamino)benzoxazole-4-carboxamide, which was converted to the dihydrochloride salt following general procedure GP-D1. 1H NMR and MS consistent.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07863271B2uspto-grants-2011_01