Reaktion #337021

ord-d5331b9e90d647ea82c6d8d980866f4f

Reaktionsgleichung

CC(C)(C)OC(=O)N1CCN(c2nc3c(C(=O)O)cccc3o2)CC1
2-[4-(tert-butoxycarbonyl)piperazin-1-yl]benzoxazole-4-carboxylic acid
Cl.Cl.N[C@@H]1CN2CCC1CC2
(S)-(−)-3-aminoquinuclidine dihydrochloride
→
CN1CCN(c2nc3c(C(=O)NC4CN5CCC4CC5)cccc3o2)[C@@H](c2ccccc2)C1
(S)—N-(quinuclidine-8-yl)-2-(4-methyl-2-phenylpiperazin-1-yl)benzoxazole-4-carboxamide

Edukte

CC(C)(C)OC(=O)N1CCN(c2nc3c(C(=O)O)cccc3o2)CC1
2-[4-(tert-butoxycarbonyl)piperazin-1-yl]benzoxazole-4-carboxylic acid
Cl.Cl.N[C@@H]1CN2CCC1CC2
(S)-(−)-3-aminoquinuclidine dihydrochloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following general procedure GP-C1, a mixture of 2-[4-(tert-butoxycarbonyl)piperazin-1-yl]benzoxazole-4-carboxylic acid and (S)-(−)-3-aminoquinuclidine dihydrochloride were coupled to provide (S)—N-(quinuclidine-8-yl)-2-(4-methyl-2-phenylpiperazin-1-yl)benzoxazole-4-carboxamide which was converted to the dihydrochloride salt following general procedure GP-D1 and isolated as a mixture of diastereomers. 1H NMR and MS consistent.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07863271B2uspto-grants-2011_01