Reaktion #337018

ord-f1b8af22538b425c9246877a3c221908

Reaktionsgleichung

C[C@@H]1CN(c2nc3c(C(=O)O)cccc3o2)C[C@H](C)O1
2-[(2S,6R)-2,6-dimethylmorpholino]benzoxazole-4-carboxylic acid
Cl.Cl.N[C@@H]1CN2CCC1CC2
(S)-(−)-3-aminoquinuclidine dihydrochloride
→
C[C@@H]1CN(c2nc3c(C(=O)N[C@@H]4CN5CCC4CC5)cccc3o2)C[C@H](C)O1
(S)—N-(quinuclidine-8-yl)-2-((2S,6R)-2,6-dimethylmorpholino)benzoxazole-4-carboxamide

Edukte

C[C@@H]1CN(c2nc3c(C(=O)O)cccc3o2)C[C@H](C)O1
2-[(2S,6R)-2,6-dimethylmorpholino]benzoxazole-4-carboxylic acid
Cl.Cl.N[C@@H]1CN2CCC1CC2
(S)-(−)-3-aminoquinuclidine dihydrochloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following general procedure GP-C1, a mixture of 2-[(2S,6R)-2,6-dimethylmorpholino]benzoxazole-4-carboxylic acid and (S)-(−)-3-aminoquinuclidine dihydrochloride were coupled to provide (S)—N-(quinuclidine-8-yl)-2-((2S,6R)-2,6-dimethylmorpholino)benzoxazole-4-carboxamide, which was converted to the hydrochloride salt following general procedure GP-D1. 1H NMR and MS consistent.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07863271B2uspto-grants-2011_01