Reaktion #337016

ord-1253244db09141cabc9b049a73721c3e

Reaktionsgleichung

CSc1nc2c(C(=O)O)cccc2o1
2-(methylthio)benzoxazole-4-carboxylic acid
Cl.Cl.N[C@@H]1CN2CCC1CC2
(S)-(−)-3-aminoquinuclidine dihydrochloride
→
CSc1nc2c(C(=O)N[C@@H]3CN4CCC3CC4)cccc2o1
(S)—N-(quinuclidine-8-yl)-2-(methylthio)benzoxazole-4-carboxamide

Edukte

CSc1nc2c(C(=O)O)cccc2o1
2-(methylthio)benzoxazole-4-carboxylic acid
Cl.Cl.N[C@@H]1CN2CCC1CC2
(S)-(−)-3-aminoquinuclidine dihydrochloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Following general procedure GP-C1, a mixture of 2-(methylthio)benzoxazole-4-carboxylic acid and (S)-(−)-3-aminoquinuclidine dihydrochloride were coupled to provide (S)—N-(quinuclidine-8-yl)-2-(methylthio)benzoxazole-4-carboxamide, which was converted to the hydrochloride salt following general procedure GP-D1. 1H NMR and MS consistent.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07863271B2uspto-grants-2011_01