Reaktion #336896

Reaktionsgleichung

1-(3-Dimethylamino-5-pentafluorosulfanyl phenyl)ethanone

trimethyl orthoformate

orthoformate

→

crude product

Ausbeute 96.9%

[3-(1,1-Dimethoxyethyl)-5-pentafluorosulfanylphenyl]dimethylamine

Ausbeute 96.9%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONtreated
2. 2
   workup.STIRRINGthe mixture was stirred for 2 h
3. 3
   workup.WAITto stand overnight
4. 4
   Sonstigethe residue was dried in a high vacuum

Vorschrift

1-(3-Dimethylamino-5-pentafluorosulfanyl phenyl)ethanone (650 mg) was dissolved in methanol (50 ml) and treated with stirring with trimethyl orthoformate (715 mg) and DL-10-camphorsulfonic acid (10 mg). After stirring for 3 h, more orthoformate (200 mg) was added, and the mixture was stirred for 2 h and then allowed to stand overnight. The solvent was then stripped off and the residue was dried in a high vacuum. 730 mg of crude product were obtained, which were reacted directly in the next stage.

Quelle