Reaktion #336663

Reaktionsgleichung

6-hydroxynicotinic acid

H2SO4

MeOH

→

methyl 6-hydroxynicotinate

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was refluxed for 10 hours
2. 2
   TemperaturAfter cooling
3. 3
   workup.DISTILLATIONMeOH was distilled off
4. 4
   FiltrationThe precipitate was collected by filtration
5. 5
   Waschenrinsed (twice) with water
6. 6
   Sonstigedried

Vorschrift

In 70 ml of MeOH was suspended 12.0 g (0.086 mole) of 6-hydroxynicotinic acid followed by addition of 4 ml of concentrated H2SO4. The mixture was refluxed for 10 hours. After cooling, MeOH was distilled off and the residue was adjusted to pH about 8 with a saturated aqueous solution of sodium hydrogen carbonate. The precipitate was collected by filtration, rinsed (twice) with water and dried to give 10.5 g of methyl 6-hydroxynicotinate as pale yellow crystals. This product was in the pyridone structure.

Quelle