Reaktion #3366

Reaktionsgleichung

4-aminophenylacetic acid

triethylamine

2-chlorosulfenylbenzoyl chloride

→

title compound

Ausbeute 69.4%

4-(3-Oxo-3h-benzo [d]isothiazol-2-yl) phenylacetic acid

Ausbeute 69.4%

Lösungsmittel

ethyl cellosolve

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated in vacuo, and water
2. 2
   workup.ADDITIONwas added to the residue
3. 3
   Filtrationfiltered

Vorschrift

To a mixture of 7.55 g (0.05 mol) of 4-aminophenylacetic acid and 15.15 g (0.15 mol) of triethylamine in 25 mL of ethyl cellosolve was added 10.3 g (0.05 mol) of 2-chlorosulfenylbenzoyl chloride (Arzneimittel Forsch., 1964;14:1301). The mixture was stirred at room temperature for 3 hours, concentrated in vacuo, and water was added to the residue. The mixture was acidified with HCl and filtered to give 9.9 g of the title compound, mp 173°-175° C.

Quelle