Reaktion #336456

Reaktionsgleichung

sodium hydroxide

1,5-dibromopentane

4-hydroxybenzophenone

→

4-[(5-bromopentyl)oxy]benzophenone

Ausbeute 78.0%

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe organic phase was separated
2. 2
   Trocknendried over sodium sulphate
3. 3
   Sonstigeevaporated

Vorschrift

100 ml of a 10 percent aqueous sodium hydroxide solution were added to a solution of 34.5 g of 1,5-dibromopentane, 9.9 g of 4-hydroxybenzophenone and 1.6 g of tetrabutylammonium bromide in 100 ml of methylene chloride. The heterogeneous mixture was stirred at room temperature overnight. The organic phase was separated, dried over sodium sulphate and evaporated. By chromatography of the residue on silica gel with hexane:ethyl acetate (7:3) there were obtained 13.47 g (78%) of 4-[(5-bromopentyl)oxy]benzophenone as a colorless oil.

Quelle