Reaktion #336441

Reaktionsgleichung

4-ethylveratrole

acetic acid

hydrobromic acid

→

4-ethylcatechol

Ausbeute 89.0%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturunder reflux for 4 hours
3. 3
   workup.ADDITIONwas added
4. 4
   Extraktionthe resultant mixture was extracted three times with each 110 ml of ether
5. 5
   ExtraktionThe ether extract
6. 6
   Waschenwas successively washed with 110 ml of water, 150 g of 5% aqueous sodium thiosulfate solution and further twice with each 110 ml of water
7. 7
   TrocknenThe resulting ether solution was dried with anhydrous sodium sulfate
8. 8
   Filtrationfiltered
9. 9
   Einengenconcentrated
10. 10
    workup.DISTILLATIONdistilled under vacuum

Vorschrift

A mixture of 10.0 g (60.2 mM) of 4-ethylveratrole, 38.4 g (639 mM) of acetic acid and 115.0 g (668 mM) of 47% hydrobromic acid was heated under reflux for 4 hours with stirring. After cooling to the room temperature, 100 ml of water was added and the resultant mixture was extracted three times with each 110 ml of ether. The ether extract was successively washed with 110 ml of water, 150 g of 5% aqueous sodium thiosulfate solution and further twice with each 110 ml of water. The resulting ether solution was dried with anhydrous sodium sulfate, filtered, concentrated and distilled under vacuum to obtain 7.4 g (53.6 mM) of 4-ethylcatechol as a light yellow liquid having a boiling point of 111°-112° C./4 mmHg.

Quelle