Reaktion #3361

Reaktionsgleichung

2-[2-(1-carboxy-2-methylbutylcarbamoyl) phenyldisulfanylbenzoylamino]-3-methylpentanoic acid

bromine

→

title compound

3-Methyl-2-(3-oxo-3h-benzo[d]isothiazol-2-yl)pentanoic acid

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated to dryness in vacuo
2. 2
   SonstigeThe residue was triturated with dichloromethane
3. 3
   SonstigeThe dichloromethane was removed by evaporation in vacuo
4. 4
   Sonstigeto remove excess bromine
5. 5
   SonstigeThe residue was partitioned between dichloromethane/5% aqueous sodium bicarbonate (200 mL each)
6. 6
   SonstigeThe aqueous layer was separated
7. 7
   Waschenwashed with fresh dichloromethane
8. 8
   ExtraktionThe acidic aqueous solution was extracted with dichloromethane (2×75 mL)
9. 9
   Waschenwashed with water
10. 10
    Trocknendried (MgSO4)
11. 11
    Filtrationfiltered
12. 12
    Einengenconcentrated to dryness in vacuo

Vorschrift

To a stirred suspension of 5.3 g (10.0 mmol) of [S-(R*,R*)]-2-[2-[2-(1-carboxy-2-methylbutylcarbamoyl) phenyldisulfanylbenzoylamino]-3-methylpentanoic acid (from Preparation 19) in 200 mL of dichloromethane was added dropwise 2.4 g (15.0 mmol) of liquid bromine. The reaction mixture was stirred at room temperature for 2 hours and concentrated to dryness in vacuo. The residue was triturated with dichloromethane. The dichloromethane was removed by evaporation in vacuo to remove excess bromine. The residue was partitioned between dichloromethane/5% aqueous sodium bicarbonate (200 mL each). The aqueous layer was separated, washed with fresh dichloromethane, and acidified to pH 1.5 with 6.0M hydrochloric acid. The acidic aqueous solution was extracted with dichloromethane (2×75 mL). The organic layers were combined, washed with water, dried (MgSO4), filtered and concentrated to dryness in vacuo to give 4.8 g of the title compound, mp 50°-52° C.

Quelle