Reaktion #336003

Reaktionsgleichung

HCl

1,3-dihydro-1,3-dioxo-2H-isoindole-2-acetyl chloride

8-chloro-10,11-dihydrodibenz[b,f][1,4]oxazepine

triethylamine

→

8-chloro-10,11-dihydro-10-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)acetyl]dibenz[b,f][1,4]oxazepine

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe insoluble product was collected by filtration
2. 2
   Waschenwashed with toluene and ethyl ether
3. 3
   Sonstigedried in vacuo at 56° C

Vorschrift

1,3-dihydro-1,3-dioxo-2H-isoindole-2-acetyl chloride (4.00 grams), 8-chloro-10,11-dihydrodibenz[b,f][1,4]oxazepine (4.16 grams) and triethylamine (2.8 mL) were refluxed in toluene (100 mL) under nitrogen for 3 hours. The resulting mixture was poured into 1N HCl at 0° C., and the biphasic mixture was shaken vigorously. The insoluble product was collected by filtration, washed with toluene and ethyl ether, and dried in vacuo at 56° C. The yield of the title compound was 6.36 grams (85%). Mp: 184°-185° C.

Quelle