Reaktion #335949

Reaktionsgleichung

potassium carbonate

1,2,4-triazole

3,4-dihydro-2-bromo-1(2H)-naphthalenone

→

product

3,4-Dihydro-2-(1H-1,2,4-triazole-1-yl)-1(2H)-Naphthalenone

Lösungsmittel

acetonitrile

dichloromethane

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONTo a mixture of 30 g
2. 2
   Sonstigeto react for 5 hours at 40° C.
3. 3
   Temperaturthan at reflux temperature for 2 hours
4. 4
   SonstigeThe solid was removed by filtration
5. 5
   Einengenthe filtrate concentrated to dryness
6. 6
   Sonstigeleaving a solid residue
7. 7
   Waschenwashed twice with water
8. 8
   ExtraktionThe organic extract
9. 9
   Trocknenwas dried over sodium sulfate
10. 10
    Sonstigeevaporated

Vorschrift

To a mixture of 30 g. potassium carbonate, 15 g. 1,2,4-triazole and 250 ml acetonitrile at 40° C. was added a solution of 45 g. 3,4-dihydro-2-bromo-1(2H)-naphthalenone in 150 ml acetonitrile. The mixture was allowed to react for 5 hours at 40° C. and than at reflux temperature for 2 hours. The solid was removed by filtration and the filtrate concentrated to dryness leaving a solid residue. This was dissolved in dichloromethane and washed twice with water. The organic extract was dried over sodium sulfate and evaporated to give 42 grams of product having a melting point of 96°-98° C.

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