Reaktion #335923

Reaktionsgleichung

3-[N-(4-fluoro-2-trifluoromethylphenyl)sulfamoyl]propionic acid

L-alanine ethyl ester hydrochloride

hydroxybenzotriazole, hydrate

triethylamine

dicyclohexylcarbodiimide

→

2-[3-[N-(4-Fluoro-2-trifluoromethylphenyl)sulfamoyl]propionylamino]-2-methylacetic Acid Ethyl Ester

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe crude product is purified by column chromatography on silica gel
2. 2
   WaschenThe title compound is eluted with ethyl acetate

Vorschrift

Under the conditions of Example 2(a), 3.152 g (10 mmol) of 3-[N-(4-fluoro-2-trifluoromethylphenyl)sulfamoyl]propionic acid, 1.536 g (10 mmol) of L-alanine ethyl ester hydrochloride, 1.531 g (10 mmol) of hydroxybenzotriazole, hydrate, as well as 1.012 g (10 mmol) of triethylamine and 2.063 g (10 mmol) of dicyclohexylcarbodiimide are reacted and worked up analogously. The crude product is purified by column chromatography on silica gel. The title compound is eluted with ethyl acetate.

Quelle