Reaktion #335800

Reaktionsgleichung

2-bromobenzonitrile

sodium carbonate

p-tolylboronic acid

→

2-cyano-4'-methylbiphenyl

Ausbeute 98.9%

Lösungsmittel

dimethoxyethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONthe following reagents added in succession
2. 2
   TemperaturThe reaction mixture was heated under an atmosphere of nitrogen at 70° to 78° C. for 19 hours
3. 3
   Sonstigethe layers separated
4. 4
   SonstigeThe organic layer was evaporated to dryness under reduced pressure
5. 5
   ExtraktionThe aqueous layer was extracted with ether (3×1.2 L)
6. 6
   workup.ADDITIONthe extracts added to the organic residue
7. 7
   FiltrationThe insoluble material was filtered off
8. 8
   Waschenwashed with ether
9. 9
   TrocknenThe filtrate was dried over anhydrous magnesium sulfate
10. 10
    Sonstigeevaporated to dryness under reduced pressure
11. 11
    FiltrationThe oily residue was filtered
12. 12
    Sonstigeto remove the solids
13. 13
    workup.DISTILLATIONthe filtrate distilled under high vacuum (0.1-0.2 torr)
14. 14
    Sonstigecollecting the fraction
15. 15
    Sonstigeboiling between 135° to 140° C.

Vorschrift

Nitrogen was bubbled through a solution of 2-bromobenzonitrile (309.4 g, 1.70 mol) in dimethoxyethane (4.2 L) for 30 minutes then the following reagents added in succession: tetrakis(triphenylphosphine)palladium(O), (95 g, 0.082 mol); 2M aqueous sodium carbonate solution (1785 mL, 3.57 mol); and p-tolylboronic acid (239.1 g, 1.76 mol). The reaction mixture was heated under an atmosphere of nitrogen at 70° to 78° C. for 19 hours. The two-phase mixture was cooled to room temperature and the layers separated. The organic layer was evaporated to dryness under reduced pressure. The aqueous layer was extracted with ether (3×1.2 L) and the extracts added to the organic residue. The insoluble material was filtered off and washed with ether. The filtrate was dried over anhydrous magnesium sulfate and evaporated to dryness under reduced pressure. The oily residue was filtered to remove the solids and the filtrate distilled under high vacuum (0.1-0.2 torr) collecting the fraction boiling between 135° to 140° C. to afford 325 g of 2-cyano-4'-methylbiphenyl. MS (DEI) 193 (M+).

Quelle