Reaktion #3352

Reaktionsgleichung

2-([2-[3-(1-tert-butoxycarbonyl-3-methyl-butylcarbamoyl)-pyridin-2-yldisulfanyl]pyridine-3-carbonyl]-amino)-4-methyl-pentanoic acid tert-butyl ester

trifluoroacetic acid

→

title compound

Ausbeute 77.4%

2-[[2-[3-(1-Carboxy-3-methylbutylcarbamoyl)-pyridin-2-yl-disulfanyl]-pyridine-3-carbonyl]-amino]-4-methyl-pentanoic acid

Ausbeute 77.4%

Lösungsmittel

anisole

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe general method of Preparation 20
2. 2
   SonstigeThe crude product was recrystallized from methanol/water

Vorschrift

The general method of Preparation 20 was followed using [S-(R*,R*)]-2-([2-[3-(1-tert-butoxycarbonyl-3-methyl-butylcarbamoyl)-pyridin-2-yldisulfanyl]pyridine-3-carbonyl]-amino)-4-methyl-pentanoic acid tert-butyl ester (1.9 g, 2.9 mmol) in 20 mL dichloromethane, anisole (1.5 mL), and 10 mL trifluoroacetic acid. The crude product was recrystallized from methanol/water to yield 1.2 g of the title compound.

Quelle