Reaktion #335165

Reaktionsgleichung

product

1-(Bromomethyl)-2-(tetradecyloxy)benzene

product

N-2-Pyridylmethylacetamide

sodium hydride

→

desired product

Ausbeute 33.7%

N-(2-Pyridinylmethyl)-N-[[2-(tetradecyloxy)phenyl]methyl]acetamide

Ausbeute 33.7%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturby heating
2. 2
   Temperaturat reflux temperature for 6 hours
3. 3
   SonstigeThe residue is purified by column chromatography (silica gel: 80% ethyl acetate/hexane)

Vorschrift

The title compound is prepared by the procedure of Example 27 using 2.45 g of product from Example 22, 0.960 g of product from Example 12, 0.322 g of washed 50% sodium hydride and 30 ml of tetrahydrofuran. The reaction is stirred at 0° C. for 1 hour, room temperature for 18 hours; followed by heating at reflux temperature for 6 hours. The residue is purified by column chromatography (silica gel: 80% ethyl acetate/hexane) to give 0.976 g of the desired product as a yellow oil. The spectral data shows the presence of 2 rotomers.

Quelle