Reaktion #334986

Reaktionsgleichung

hydrochloric acid

2-fluoro-4-hydroxybenzoic acid

tridecanoyl chloride

dimethylaminopyridine

→

titled compound

Ausbeute 59.4%

2-fluoro-4-n-tridecanoyloxybenzoic acid

Ausbeute 59.4%

Lösungsmittel

dichloromethane

triethylamine

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe organic layer was separated by a funnel
2. 2
   workup.DISTILLATIONdistilled
3. 3
   Sonstigeto remove the solvent
4. 4
   WaschenThe residue was washed with n-hexane
5. 5
   Sonstigedried

Vorschrift

To a solution of 2-fluoro-4-hydroxybenzoic acid (1.4 g) and triethylamine (1.0 g) in dichloromethane (40 ml) were added tridecanoyl chloride (2.0 g) and dimethylaminopyridine (0.2 g). The solution was stirred at room temperature for about 20 hours and thereto was added dilute aqueous hydrochloric acid solution. The organic layer was separated by a funnel and distilled to remove the solvent. The residue was washed with n-hexane and dried to obtain the titled compound (about 1.8 g).

Quelle