Reaktion #334985

Reaktionsgleichung

hydrochloric acid

2-fluoro-4-hydroxybenzoic acid

decanoylchloride

dimethylaminopyridine

→

titled compound

Ausbeute 70.4%

2-fluoro-4-n-decanoyloxybenzoic acid

Ausbeute 70.4%

Lösungsmittel

dichloromethane

triethylamine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe organic layer was separated by a funnel
2. 2
   workup.DISTILLATIONThe layer was distilled
3. 3
   Sonstigeto remove the solvent
4. 4
   WaschenThe residue was washed with n-hexane
5. 5
   Sonstigedried

Vorschrift

To a solution of 2-fluoro-4-hydroxybenzoic acid (2 g) and triethylamine (1.4 g) in dichloromethane (40 ml) were added decanoylchloride (2.7 g) and dimethylaminopyridine (0.2 g). The solution was stirred at room temperature for about 20 hours. To the solution was added dilute aqueous hydrochloric acid solution and the organic layer was separated by a funnel. The layer was distilled to remove the solvent. The residue was washed with n-hexane and dried to obtain the titled compound (about 2.8 g).

Quelle