Reaktion #3344

Reaktionsgleichung

8-bromomethylquinoline

5,5-dimethyl-2,4-dithiohydantoin

→

desired compound

2,4-bis-(8-quinolinylmethylthio)-5,5-dimethyl-5H-imidazole

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated in vacuo
2. 2
   workup.ADDITIONTo the residue, 100 mL of CHCl3 was added
3. 3
   WaschenThe mixture was washed with an aqueous solution of K2CO3
4. 4
   Trocknendried over MgSO4
5. 5
   Einengenconcentrated in vacuo
6. 6
   SonstigeThe residue was purified by column chromatograph (CHCl3)
7. 7
   SonstigeRecrystallization from diethyl ether

Vorschrift

Initially, 3 g of 8-bromomethylquinoline was added to a solution of 1 g of 5,5-dimethyl-2,4-dithiohydantoin in 50 mL of ethanol (EtOH). The reaction mixture was stirred at the room temperature for 1.5 hour, and concentrated in vacuo. To the residue, 100 mL of CHCl3 was added. The mixture was washed with an aqueous solution of K2CO3, dried over MgSO4 and concentrated in vacuo. The residue was purified by column chromatograph (CHCl3). Recrystallization from diethyl ether gave the desired compound in the form of a needle-like crystal. The yield of this compound was 2.3 g with a yield ratio of 83.3%, and the melting point was 101°-104° C.

Quelle