Reaktion #334307

ord-2392f2e657514f2db6cbb02937a0862c

Reaktionsgleichung

COC(=O)C(=Cc1cccc([N+](=O)[O-])c1)C(C)=O
methyl 2-(3-nitrobenzylidene)acetoacetate
CC(=O)Cc1nc(CN(C)Cc2ccccc2)no1
5-acetonyl-3-(N-benzyl-N-methylamino)methyl-1,2,4-oxadiazole
N.O
ammonia water
→
COC(=O)C1=C(C)NC(C)=C(c2nc(CN(C)Cc3ccccc3)no2)C1c1cccc([N+](=O)[O-])c1
methyl 1,4-dihydro-2,6-dimetyl-3-[3-(N-benzyl-N-methylamino)methyl-1,2,4-oxadiazol-5-yl]-4-(3-nitrophenyl)pyridine-5-carboxylate

Edukte

COC(=O)C(=Cc1cccc([N+](=O)[O-])c1)C(C)=O
methyl 2-(3-nitrobenzylidene)acetoacetate
CC(=O)Cc1nc(CN(C)Cc2ccccc2)no1
5-acetonyl-3-(N-benzyl-N-methylamino)methyl-1,2,4-oxadiazole
N.O
ammonia water

Reagenzien

Keine

Lösungsmittel

CC(C)O
isopropyl alcohol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigewas reacted

Vorschrift

A mixture of 250 mg of methyl 2-(3-nitrobenzylidene)acetoacetate, 260 mg of 5-acetonyl-3-(N-benzyl-N-methylamino)methyl-1,2,4-oxadiazole, 3 ml of isopropyl alcohol and 40 mg of 29% ammonia water was reacted and worked up as described in Example 104 to give methyl 1,4-dihydro-2,6-dimetyl-3-[3-(N-benzyl-N-methylamino)methyl-1,2,4-oxadiazol-5-yl]-4-(3-nitrophenyl)pyridine-5-carboxylate, m.p. 126°-127° C.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04705786uspto-grants-1987_11