Reaktion #333855

Reaktionsgleichung

water

3-iodo-6-methyl-1H-indazole

2-chloro-N,N-dimethylethanamine hydrochloride

potassium carbonate

→

2-(3-iodo-6-methyl-1H-indazol-1-yl)-N,N-dimethylethanamine

Ausbeute 151.9%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated to 80 degree overnight
2. 2
   Extraktionproduct extracted with dichloromethane (3×50 mL)
3. 3
   Trocknencombined organics were dried with sodium sulfate
4. 4
   Einengenconcentrated

Vorschrift

A mixture of 3-iodo-6-methyl-1H-indazole (516 mg, 2 mmol), 2-chloro-N,N-dimethylethanamine hydrochloride (346 mg, 2.4 mmol) and potassium carbonate (828 mg, 6 mmol) in 20 mL of DMF was heated to 80 degree overnight. After cooling to room temperature, water (50 mL) was added, product extracted with dichloromethane (3×50 mL), combined organics were dried with sodium sulfate, and concentrated to give 2-(3-iodo-6-methyl-1H-indazol-1-yl)-N,N-dimethylethanamine (1 g, 100%). 1H NMR (300 MHz, CDCl3): δ 7.33 (d, 1H, J=8.1 Hz), 7.15 (s, 1H), 7.03 (d, 1H, J=0.6 Hz), 4.47 (t, 2H, J=7.2 Hz), 2.81 (t, 2H, J=7.2 Hz), 2.51 (s, 3H), 2.34 (m, 6H).

Quelle