Reaktion #333824

Reaktionsgleichung

6-chloro-1H-indazole

KOH

I2

→

6-chloro-3-iodo-1H-indazole

Ausbeute 83.0%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeReaction
2. 2
   Sonstigequenched with water, product
3. 3
   Extraktionwas extracted with ethyl acetate (150 mL), organic phase
4. 4
   Waschenwashed with water (3×10 mL), brine (2×10 mL)
5. 5
   Trocknendried over Na2SO4
6. 6
   Filtrationfiltered
7. 7
   Einengenconcentrated

Vorschrift

A mixture of 6-chloro-1H-indazole (2 g, 13.1 mmol), KOH (2.2 g, 39.3 mmol) and I2 (6.6 g, 26.2 mmol) in dry DMF (20 mL) was heated to 30° C. for 16 hours. Reaction quenched with water, product was extracted with ethyl acetate (150 mL), organic phase washed with water (3×10 mL), brine (2×10 mL) and dried over Na2SO4, then filtered and concentrated to afford 6-chloro-3-iodo-1H-indazole (3.0 g, 83%) as a yellow solid. LCMS: (M+H)+=279.

Quelle