Reaktion #332136

Reaktionsgleichung

1-(2-azido-2-methylpropyl)-4-(trifluoromethyl)benzene

hydrogen

→

desired product

Ausbeute 18.8%

2-methyl-1-(4-(trifluoromethyl)phenyl)propan-2-amine

Ausbeute 18.8%

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter completion of the reaction
2. 2
   Filtrationthe palladium hydroxide carbon was filtered off
3. 3
   workup.ADDITIONthe filtrate was mixed with 3 M hydrochloric acid
4. 4
   Sonstigeseparated
5. 5
   Extraktionextracted with methylene chloride
6. 6
   EinengenThe organic layer was concentrated under reduced pressure

Vorschrift

25.4 g of 1-(2-azido-2-methylpropyl)-4-(trifluoromethyl)benzene was dissolved in 210 mL of ethyl acetate and mixed with 0.84 g of 20 wt % palladium hydroxide carbon. The atmosphere in the reaction vessel was replaced with hydrogen gas, and the reaction solution was stirred at room temperature for 18 hours. After completion of the reaction, the palladium hydroxide carbon was filtered off, and the filtrate was mixed with 3 M hydrochloric acid and separated. The aqueous layer was basified with 5 M sodium hydroxide and extracted with methylene chloride. The organic layer was concentrated under reduced pressure to give 4.27 g of the desired product as a brown liquid.

Quelle