Reaktion #332113

Reaktionsgleichung

2-methyl-1-p-tolylpropan-2-amine

t-butyl 3-(trichloromethyl)-1,2-oxaziridine-2-carboxylate

→

desired product

t-butyl 2-(2-methyl-1-p-tolylpropan-2-yl)hydrazinecarboxylate

Lösungsmittel

methylene chloride

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturunder cooling with ice
2. 2
   Sonstigethe methylene chloride was removed under reduced pressure
3. 3
   SonstigeThe resulting residue was purified by silica gel column chromatography

Vorschrift

2.40 g (14.7 mmol) of separately prepared 2-methyl-1-p-tolylpropan-2-amine was dissolved in 20 mL of methylene chloride, and 2.60 g (10.0 mmol) of separately prepared t-butyl 3-(trichloromethyl)-1,2-oxaziridine-2-carboxylate in 10 mL of methylene chloride was added under cooling with ice. The reaction slution was stirred under cooling with ice for 30 minutes and at room temperature for 1 hour, and the methylene chloride was removed under reduced pressure. The resulting residue was purified by silica gel column chromatography using hexane-ethyl acetate (100:0 to 0:100) as the eluent to give 1.61 g of the desired product as colorless crystals.

Quelle