Reaktion #332112

Reaktionsgleichung

sodium hydroxide

2-chloro-N-(2-methyl-1-p-tolylpropan-2-yl)acetamide

thiourea

acetic acid

→

desired product

Ausbeute 95.2%

2-methyl-1-p-tolylpropan-2-amine

Ausbeute 95.2%

Lösungsmittel

ethanol

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto cool
2. 2
   Extraktionextracted with hexane
3. 3
   Waschenthe extract was washed with saturated aqueous sodium chloride
4. 4
   EinengenThe organic layer was concentrated under reduced pressure

Vorschrift

6.24 g (26.0 mmol) of 2-chloro-N-(2-methyl-1-p-tolylpropan-2-yl)acetamide and 1.98 g (26.0 mmol) of thiourea were dissolved in 50 mL of ethanol, and 10.2 mL of acetic acid was added dropwise at room temperature. After 3 hours of stirring at 85° C. the resulting white suspension was allowed to cool and diluted with 300 mL of water. The reaction solution was basified with 20 wt % aqueous sodium hydroxide and extracted with hexane, and the extract was washed with saturated aqueous sodium chloride. The organic layer was concentrated under reduced pressure to give 4.04 g of the desired product as a yellow green liquid.

Quelle