Reaktion #331706

Reaktionsgleichung

Methanesulphonyl chloride

N,N-dimethyl-1,3-phenylenediamine

sodium hydroxide

→

material

Ausbeute 79.0%

N-[3-(dimethylamino)phenyl]methanesulphonamide

Ausbeute 79.0%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionThe mixture was extracted with chloroform (3×15 cm3)
2. 2
   TrocknenThe combined extracts were dried over sodium sulphate
3. 3
   Filtrationfiltered
4. 4
   Sonstigethe solvent removed under reduced pressure

Vorschrift

Methanesulphonyl chloride (838 mg, 7.35 mmol) was added slowly to a cooled solution (5° C.) of N,N-dimethyl-1,3-phenylenediamine (1.00 g, 7.35 mmol) and sodium hydroxide (5M, 1.5 cm3) in water (10 cm3). The reaction was allowed to warm to room temperature overnight. The mixture was extracted with chloroform (3×15 cm3). The combined extracts were dried over sodium sulphate, filtered and the solvent removed under reduced pressure. Column chromatography (1:20 methanol/dichloromethane) gave the target material as a brown oil (1.24 g, 79%).

Quelle