Reaktion #329012

Reaktionsgleichung

1-ethylpiperazine

K2CO3

propargyl bromide

→

1-ethyl-4-prop-2-ynyl-piperazine

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction was filtered
2. 2
   Waschenthe salts washed with a small amount of acetone
3. 3
   Sonstigeevaporated gently to concentration
4. 4
   Waschenwashed with water
5. 5
   ExtraktionThe aqueous phase was re-extracted with EtOAc
6. 6
   WaschenThe combined organic layers were washed with brine
7. 7
   Trocknendried over MgSO4
8. 8
   FiltrationThe product was filtered
9. 9
   Sonstigeevaporated to dryness
10. 10
    Sonstigeto leave a pale orange oil

Vorschrift

To the 1-ethylpiperazine (2.33 g, 20.2 mmol) and K2CO3 (2.79 g, 20.2 mmol) in acetone (27 ml) was added propargyl bromide (2.00 g, 13.5 mmol) dropwise at 0° C. under N2. The reaction was stirred at room temperature overnight. The reaction was filtered and the salts washed with a small amount of acetone. The filtrates were combined and evaporated gently to concentration. The residue was taken up in EtOAc and washed with water. The aqueous phase was re-extracted with EtOAc. The combined organic layers were washed with brine and dried over MgSO4. The product was filtered and evaporated to dryness to leave a pale orange oil.

Quelle