Reaktion #328989

Reaktionsgleichung

hydrazone

2-[(3,4-Dimethoxy-phenyl)-hydrazono]-3-oxo-pentanedioic acid dimethyl ester

cyclohexane

→

dihydropyridazine ester

Ausbeute 65.2%

1-(3,4-Dimethoxy-phenyl)-4-hydroxy-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid methyl ester

Ausbeute 65.2%

Lösungsmittel

dichlorobenzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturheated
2. 2
   Temperaturto reflux in a sealed tube for 4 hours
3. 3
   Temperaturto cool
4. 4
   Sonstigeto crystallize the desired product
5. 5
   FiltrationFiltration
6. 6
   Sonstigedrying in vacuo

Vorschrift

The hydrazone (28) (500 mg) was dissolved in dichlorobenzene and heated to reflux in a sealed tube for 4 hours. The reaction was allowed to cool and cyclohexane was added dropwise to crystallize the desired product. Filtration and drying in vacuo yielded the desired dihydropyridazine ester (29) (295 mg) as a solid. MS+: m/e=307.0 (M+H).

Quelle