Reaktion #328594

Reaktionsgleichung

NaOH

2-amino-5-bromonicotinic acid

pyridine-2,3-diamine

→

5-bromo-3-(1H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-ylamine

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture is cooled to room temperature
2. 2
   SonstigeThe precipitate formed
3. 3
   Filtrationis filtered off with suction
4. 4
   Sonstigedried

Vorschrift

50 mg (0.230 mmol) I) of 2-amino-5-bromonicotinic acid and 27.6 mg (0.253 mmol) of pyridine-2,3-diamine are added to 451.5 mg (5 mmol) of polyphosphoric acid, and the mixture is stirred at 160° C. for 4 days. The reaction mixture is cooled to room temperature, water is added, and the mixture is adjusted to pH 12 by means of 1N NaOH. The precipitate formed is filtered off with suction and dried, giving 5-bromo-3-(1H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-ylamine.

Quelle