Reaktion #328214

ord-dcf8639aceb34a2cb462eec33a2473f6

Reaktionsgleichung

Nc1ccc(Br)cc1N
4-bromobenzene-1,2-diamine
O=C(O)CF
fluoroacetic acid
CC(C)COC(=O)Cl
isobutyl chloroformate
→
CC(C)COC(=O)n1c(CF)nc2cc(Br)ccc21
2-Methylpropyl 5-bromo-2-(fluoromethyl)-1H-benzimidazole-1-carboxylate

Edukte

Nc1ccc(Br)cc1N
4-bromobenzene-1,2-diamine
O=C(O)CF
fluoroacetic acid
CC(C)COC(=O)Cl
isobutyl chloroformate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeSynthesized

Vorschrift

Synthesized according to the method of reagent preparation 19 using 4-bromobenzene-1,2-diamine and fluoroacetic acid in step 1 then treatment with isobutyl chloroformate in step 3. MS (EI) for C13H14BrFN2O2: 330 (MH+).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08648066B2uspto-grants-2014_02