Reaktion #327980

Reaktionsgleichung

water

1H-Indazole-3-carboxylic acid

carbonyl diimidazole

dimethylamine hydrochloride

→

title compound

N,N-dimethyl-1H-indazole-3-carboxamide

Lösungsmittel

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionthe aqueous phase was extracted with ethyl acetate (3×150 mL)
2. 2
   WaschenThe combined organic phases were washed sequentially with aqueous sodium bicarbonate, 10% hydrochloric acid, water and brine
3. 3
   TrocknenAfter drying over magnesium sulfate
4. 4
   Filtrationfiltering
5. 5
   Einengenconcentrating in vacuo

Vorschrift

1H-Indazole-3-carboxylic acid (5.0 g, 30.8 mmol) and carbonyl diimidazole (5.0 g, 33.9 mmol) were dissolved in N,N-dimethylformamide (150 mL) and heated to 60° C. After 2 hours, dimethylamine hydrochloride (4.0 g, 33.9) was added, and the reaction was stirred for an additional hour at 60° C. The reaction was poured into water, and the aqueous phase was extracted with ethyl acetate (3×150 mL). The combined organic phases were washed sequentially with aqueous sodium bicarbonate, 10% hydrochloric acid, water and brine. After drying over magnesium sulfate, filtering and concentrating in vacuo, the title compound was obtained.

Quelle